ODCs

Click node...

1 OMIM reference -
1 associated gene
12 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 4

3 OMIM references -
5 associated genes
17 signs/symptoms

Alpha-thalassemia - myelodysplastic syndrome

Essential thrombocythemia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	ATRX	(0.63)	TP53

Citations in the biomedical literature:

Alpha-thalassemia - myelodysplastic syndrome		Essential thrombocythemia
	Synonym(s): - ATMDS - Acquired HbH disease - Acquired hemoglobin H disease		Synonym(s): - ET - Essential thrombocytosis

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adulthood Average age of death: elderly Type of inheritance: sporadic		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: adulthood Average age of death: normal Type of inheritance: sporadic

	External references: 1 OMIM reference - No MeSH references		External references: 3 OMIM references - 1 MeSH reference: D013920


COMMON SIGNS	- Acute leukemia - Hemorrhage / hemorrhagic syndrome / excessive / long-lasting bleeding - Myelodysplastic syndrome - Splenomegaly

Alpha-thalassemia - myelodysplastic syndrome		Essential thrombocythemia
	Very frequent - Asthenia / fatigue / weakness - Microcytic anemia - Polynuclear cells / neutrophils anomalies / neutropenia - Thrombocytopenia / thrombopenia Frequent - Bruisability - Respiratory distress / dyspnea / respiratory failure / lung volume reduction Occasional - Immunodeficiency / increased susceptibility to infections / recurrent infections - Neoplasms / tumors		Very frequent - Acute ischemic syndrome - Angor pectoris / myocardial infarction - Arterial embolism / thrombosis - Bone marrow anomalies - Cerebral vascular anomalies - Paresthesia / dysesthesia / hypoesthesia / anesthesia / numbness - Platelet disorders / thrombopathies - Platelets shape anomalies - Thoracic / chest pain - Transient amaurosis / acute visual trouble - Transient cerebral ischemia / stroke - Venous thrombosis / phlebitis / thrombophlebitis Occasional - Myeloproliferative syndrome / chronic leukemia